Nature Communications (May 2019)

Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them

  • Ahmed A. Quadeer,
  • Raymond H. Y. Louie,
  • Matthew R. McKay

DOI
https://doi.org/10.1038/s41467-019-09819-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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A good vaccine should direct the immune response to virus regions that are most difficult to escape. Here, Quadeer et al. develop a predictive in-silico evolutionary model for HCV E2 which identifies one such antigenic region and identifies multiple broadly neutralizing human antibodies that appear difficult to escape from.