Nature Communications (Jan 2022)
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice
- Barbara Spix,
- Elisabeth S. Butz,
- Cheng-Chang Chen,
- Anna Scotto Rosato,
- Rachel Tang,
- Aicha Jeridi,
- Veronika Kudrina,
- Eva Plesch,
- Philipp Wartenberg,
- Elisabeth Arlt,
- Daria Briukhovetska,
- Meshal Ansari,
- Gizem Günes Günsel,
- Thomas M. Conlon,
- Amanda Wyatt,
- Sandra Wetzel,
- Daniel Teupser,
- Lesca M. Holdt,
- Fabien Ectors,
- Ingrid Boekhoff,
- Ulrich Boehm,
- Jaime García-Añoveros,
- Paul Saftig,
- Martin Giera,
- Sebastian Kobold,
- Herbert B. Schiller,
- Susanna Zierler,
- Thomas Gudermann,
- Christian Wahl-Schott,
- Franz Bracher,
- Ali Önder Yildirim,
- Martin Biel,
- Christian Grimm
Affiliations
- Barbara Spix
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Elisabeth S. Butz
- Department of Pharmacy, Ludwig-Maximilians-University
- Cheng-Chang Chen
- Department of Pharmacy, Ludwig-Maximilians-University
- Anna Scotto Rosato
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Rachel Tang
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Aicha Jeridi
- Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Veronika Kudrina
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Eva Plesch
- Department of Pharmacy, Ludwig-Maximilians-University
- Philipp Wartenberg
- Saarland University, Center for Molecular Signaling (PZMS), Experimental Pharmacology
- Elisabeth Arlt
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Daria Briukhovetska
- Division of Clinical Pharmacology, Department of Medicine IV, University Hospital Munich
- Meshal Ansari
- Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Gizem Günes Günsel
- Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Thomas M. Conlon
- Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Amanda Wyatt
- Saarland University, Center for Molecular Signaling (PZMS), Experimental Pharmacology
- Sandra Wetzel
- Institute of Biochemistry, Christian-Albrechts-University Kiel
- Daniel Teupser
- Institute of Laboratory Medicine, University Hospital Munich
- Lesca M. Holdt
- Institute of Laboratory Medicine, University Hospital Munich
- Fabien Ectors
- FARAH Mammalian Transgenics Platform, Liège University
- Ingrid Boekhoff
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Ulrich Boehm
- Saarland University, Center for Molecular Signaling (PZMS), Experimental Pharmacology
- Jaime García-Añoveros
- Departments of Anesthesiology, Physiology and Neurology, Northwestern University, Feinberg School of Medicine
- Paul Saftig
- Institute of Biochemistry, Christian-Albrechts-University Kiel
- Martin Giera
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Sebastian Kobold
- Division of Clinical Pharmacology, Department of Medicine IV, University Hospital Munich
- Herbert B. Schiller
- Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Susanna Zierler
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Thomas Gudermann
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- Christian Wahl-Schott
- Institute for Neurophysiology, Hannover Medical School
- Franz Bracher
- Department of Pharmacy, Ludwig-Maximilians-University
- Ali Önder Yildirim
- Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Martin Biel
- Department of Pharmacy, Ludwig-Maximilians-University
- Christian Grimm
- Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University
- DOI
- https://doi.org/10.1038/s41467-021-27860-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.
