PLACE OF RESPIRATORY FLUOROQUINOLONES IN THERAPY OF COMMUNITY ACQUIRED PNEUMONIA: FOCUS ON HIGH-DOSE LEVOFLOXACINE THERAPEUTIC REGIME

Abstract

Community-acquired pneumonia is one of the most prevalent infectious diseases and there are numerous diagnostic and therapeutic mistakes in relation to it. Prescription of the antibiotics to CAP patients remains a classic example of “educated guess”. Today one can find antibiotics active against a large range of intra- and extracellular causative agents able to prolong widely spread mechanism of resistance of major respiratory pathogens. The modern practice of clinical application of levofloxacin simultaneously demonstrates possibilities of modification of dosing regimes, safe reduction of the time of administration of the drug, minimization of the risk of selection of drug resistance of the disease causative agents, reduction of frequency and intensity of drug reactions.

Keywords

• community-acquired pneumonia
• antibiotic therapy
• fluoroquinolones
• levofloxacin