Effect of potassium chloride and actovegin infusions on cardiohemodynamics and enzymemia in acute period of myocardial infarction among patients with left ventricular systolic dysfunction

Abstract

То investigate effect of potassium chloride and its combination with actovegin infusions on cardiohemodynamics and CK, AsAT, myoglobine levels in AMI associated with left ventricular systolic dysfunction, two groups of patients were examined. Participants from the first group (n=26) received infusions of 1 % potassium chloride (4-6 g/d). In the second group, patients (n=23) received infusions of 1 % potassium chloride plus actovegin (0. 15-0. 3 mg/kg/h; 160-320mg/d). Comparative analysis of the data obtained revealed that, after infusion of potassium chloride plus actovegin (0. 15-0. 3 mg/kg/h), left ventriclar volumes reduced, IV contractility improved, BP and cardiac output increased, together with decrease in CVP, HR, DP (double product), and CK activity.

Keywords

• acute myocardial infarction
• left ventricular systolic dysfunction
• potassium chloride
• actovegin
• cytoprotection