<italic toggle="yes">MetaMed</italic>: Linking Microbiota Functions with Medicine Therapeutics
Han Zhao,
Shaliu Fu,
Yifei Yu,
Zhanbing Zhang,
Ping Li,
Qin Ma,
Wei Jia,
Kang Ning,
Shen Qu,
Qi Liu
Affiliations
Han Zhao
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Shaliu Fu
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Yifei Yu
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Zhanbing Zhang
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Ping Li
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Qin Ma
Department of Mathematics and Statistics, South Dakota State University, Brookings, South Dakota, USA
Wei Jia
R&D Information, Innovation Center China, AstraZeneca, Shanghai, China
Kang Ning
School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
Shen Qu
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Qi Liu
Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
ABSTRACT Understanding how the human microbiome affects human health has consequences for treating disease and minimizing unwanted side effects in clinical research. Here, we present MetaMed (http://metamed.rwebox.com/index), a novel and integrative system-wide correlation mapping system to link bacterial functions and medicine therapeutics, providing novel hypotheses for deep investigation of microbe therapeutic effects on human health. Furthermore, comprehensive relationships between microbes living in the environment and drugs were discovered, providing a rich source for discovering microbiota metabolites with great potential for pharmaceutical applications.
