EFFECT OF AMYLOID FIBRILS ON ELECTROKINETIC PROPERTIES OF LIPID VESICLES

East European Journal of Physics. 2017;4(2):19-28

 

Journal Homepage

Journal Title: East European Journal of Physics

ISSN: 2312-4334 (Print); 2312-4539 (Online)

Publisher: V.N. Karazin Kharkiv National University Publishing

Society/Institution: V.N. Karazin Kharkiv National University

LCC Subject Category: Science: Physics

Country of publisher: Ukraine

Language of fulltext: Ukrainian, English, Russian

Full-text formats available: PDF

 

AUTHORS

U. Tarabara (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)
K. Vus (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)
S. Girnyk (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)
N. Kamneva (Department of Physical Chemistry, V.N. Karazin Kharkiv National University 4 Svobody Sq., Kharkiv, 61022, Ukraine)
O. Lavryk (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)
M. Mikhailyuta (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)
V. Trusova (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)
G. Gorbenko (Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text

The influence of the lysozyme and serum albumin in their native and amyloid forms on the electrokinetic behavior of the negatively charged uni- and multilamellar liposomes from the zwitterionic lipid phosphatidylcholine and anionic lipid cardiolipin has been investigated using the microelectrophoresis technique. The zeta - potential, the surface electrostatic potential and surface charge density of the lipid vesicles have been determined upon varying the lipid-to-protein molar ratio. The complex dependencies of the electrophoretic mobility on the protein concentration and reversal of the surface charge observed for the multilamellar vesicles have been explained by the multilayer protein adsorption on the liposomal surface. It has been found that the native and fibrillar proteins differ in their ability to modify the charge state of the model membranes.