Effects of endogenous FMRFamide-like peptides on muscles of distal part of reproductive system females Ascaria suum

Abstract

Development of drug resistance in parasitic organisms, including nematodes, makes it necessary, on one side to study molecular mechanisms of such resistance formation, on the other side, to find new biological targets to reduce the spread of infections. One of such targets in parasitic nematodes may be a distal section of nematode female reproductive system - vagina or ovijector. It is a critically important muscle organ of nematodes reproductive system with main physiological functions of ejecting infective eggs into host intestine and catching male sperm. The goal of the article is review and analysis of literature data on effects of some endogenous neuropeptides (FMRF-like peptides) on muscles of distal part of vagina vera of Ascaris suum parasitic nematode. The article also considered possibilities for using a distal part of reproductive system of female nematodes as one of biological targets for potential anthelmintics synthesized on the basis of FMRFamide-like neuropeptides to fight against nematodosis of humans, animals and plants.

Keywords

• нематоды
• репродуктивная система
• вагина
• fmrfамид - подобные нейропептиды
• nematodes
• reproductive system
• vagina vera
• fmrfamide-like neuropeptides