Türk Biyokimya Dergisi (Aug 2022)

Modulatory effect of pomegranate extract on TRPA1, TRPM2 and caspase-3 expressions in colorectal cancer induction of mice

  • Kaya İnan,
  • Dağ Serpil,
  • Mavioğlu Kaya Müge,
  • Tanrıverdi Erdi Anil,
  • Beşeren Hatice,
  • Aşasın Gizem

DOI
https://doi.org/10.1515/tjb-2022-0099
Journal volume & issue
Vol. 47, no. 5
pp. 612 – 619

Abstract

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This study aimed to evaluate the effects of pomegranate fruit extract (PFE) on levels of transient receptor potential (TRP) channel and caspase-3 (Casp-3) expressions, tumor necrosis factor-α (TNF-α), total sialic acid (TSA), reduced glutathione (GSH), and malondialdehyde (MDA) in mice with induced colorectal cancer (CRC) by investigating effects of PFE on in vitro mitotic index (MI).

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