Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase

Zuodong Sun; Cooper S. Jamieson; Masao Ohashi; K. N. Houk; Yi Tang

doi:10.1038/s41467-022-30288-6

Nature Communications (May 2022)

Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase

Zuodong Sun,
Cooper S. Jamieson,
Masao Ohashi,
K. N. Houk,
Yi Tang

Affiliations

Zuodong Sun: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles
Cooper S. Jamieson: Department of Chemistry and Biochemistry, University of California, Los Angeles
Masao Ohashi: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles
K. N. Houk: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles
Yi Tang: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-022-30288-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Pericyclase enzymes are an expanding family of enzymes. Here, the authors identify the norbornene synthase SdnG, a pericyclase for the intramolecular Diels-Alder reaction between a cyclopentadiene and an olefinic dienophile to form the sordaricin norbornene structure, and reconstitute the sordaricin biosynthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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