Nature Communications (Jul 2018)
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
- Caitlin L. Grzeskowiak,
- Samrat T. Kundu,
- Xiulei Mo,
- Andrei A. Ivanov,
- Oksana Zagorodna,
- Hengyu Lu,
- Richard H. Chapple,
- Yiu Huen Tsang,
- Daniela Moreno,
- Maribel Mosqueda,
- Karina Eterovic,
- Jared J. Fradette,
- Sumreen Ahmad,
- Fengju Chen,
- Zechen Chong,
- Ken Chen,
- Chad J. Creighton,
- Haian Fu,
- Gordon B. Mills,
- Don L. Gibbons,
- Kenneth L. Scott
Affiliations
- Caitlin L. Grzeskowiak
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Samrat T. Kundu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xiulei Mo
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine
- Andrei A. Ivanov
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine
- Oksana Zagorodna
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Hengyu Lu
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Richard H. Chapple
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Yiu Huen Tsang
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Daniela Moreno
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Maribel Mosqueda
- Department of Systems Biology, University of Texas MD Anderson Cancer Center
- Karina Eterovic
- Department of Systems Biology, University of Texas MD Anderson Cancer Center
- Jared J. Fradette
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Sumreen Ahmad
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Fengju Chen
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- Zechen Chong
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Ken Chen
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Chad J. Creighton
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- Haian Fu
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine
- Gordon B. Mills
- Department of Systems Biology, University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Kenneth L. Scott
- Department of Molecular and Human Genetics, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-04572-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
KRAS-driven lung cancers represent an aggressive form of NSCLC. In this study the authors perform an in vivo functional screening and identify GATAD2B as a driver of tumor growth and metastasis in KRAS-driven lung cancer.
