Fibrane the reduced derivative of fenofibrate

Amanda E. Kotheimer; Wahajul Haq; Ganesaratnam K. Balendiran

Results in Chemistry (Jan 2020)

Fibrane the reduced derivative of fenofibrate

Amanda E. Kotheimer,
Wahajul Haq,
Ganesaratnam K. Balendiran

Affiliations

Amanda E. Kotheimer: Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
Wahajul Haq: Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
Ganesaratnam K. Balendiran: Corresponding author.; Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA

Journal volume & issue: Vol. 2
p. 100018

Abstract

Read online

Synthetic routes for the preparation of (i) isopropyl 2-(4-(4-chlorobenzyl)phenoxy)-2-methyl propanoate (Reduced Fenofibrate, Fibrane) (2) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate) (1) in a single step is established in good yield and purity under mild conditions. The newly synthesized derivative of Fenofibrate has been characterized by NMR and IR spectroscopy techniques. Selective conversion of biphenyl ketone moiety, in the presence of ester carbonyl group in Fenofibrate to its corresponding alkane can be performed by Pd catalyst reduction with hydrogen transfer agent ammonium formate.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

About the journal

Abstract

Keywords