Nature Communications (Jun 2019)

Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

  • Marti Quevedo,
  • Lize Meert,
  • Mike R. Dekker,
  • Dick H. W. Dekkers,
  • Johannes H. Brandsma,
  • Debbie L. C. van den Berg,
  • Zeliha Ozgür,
  • Wilfred F. J. van IJcken,
  • Jeroen Demmers,
  • Maarten Fornerod,
  • Raymond A. Poot

DOI
https://doi.org/10.1038/s41467-019-10502-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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The Mediator complex regulates transcription by connecting enhancers to promoters. Here, the authors purify Mediator from neural stem cells (NSCs), identify 75 novel protein-protein interaction partners and characterize the Mediator-interacting network that regulates transcription and establishes NSC identity.