Nature Communications (Jun 2021)
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
- Zipeng Zeng,
- Biao Huang,
- Riana K. Parvez,
- Yidan Li,
- Jyunhao Chen,
- Ariel C. Vonk,
- Matthew E. Thornton,
- Tadrushi Patel,
- Elisabeth A. Rutledge,
- Albert D. Kim,
- Jingying Yu,
- Brendan H. Grubbs,
- Jill A. McMahon,
- Nuria M. Pastor-Soler,
- Kenneth R. Hallows,
- Andrew P. McMahon,
- Zhongwei Li
Affiliations
- Zipeng Zeng
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Biao Huang
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Riana K. Parvez
- Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Yidan Li
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Jyunhao Chen
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Ariel C. Vonk
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Matthew E. Thornton
- Division of Maternal Fetal Medicine, Keck School of Medicine, University of Southern California
- Tadrushi Patel
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Elisabeth A. Rutledge
- Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Albert D. Kim
- Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Jingying Yu
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Brendan H. Grubbs
- Division of Maternal Fetal Medicine, Keck School of Medicine, University of Southern California
- Jill A. McMahon
- Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Nuria M. Pastor-Soler
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Kenneth R. Hallows
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- Andrew P. McMahon
- Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Zhongwei Li
- USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California
- DOI
- https://doi.org/10.1038/s41467-021-23911-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Here, the authors model the collecting duct system in kidneys by taking ureteric bud (UB) progenitor cells from both mouse and human primary tissues, as well as from hESC and hiPSC to generate organoids, which can model congenital anomalies of the kidney and urinary tract.
