Frontiers in Oncology (Mar 2021)

Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

  • Cathryn B. Crockett,
  • Pamela Samson,
  • Robert Chuter,
  • Robert Chuter,
  • Michael Dubec,
  • Michael Dubec,
  • Corinne Faivre-Finn,
  • Corinne Faivre-Finn,
  • Olga L. Green,
  • Sara L. Hackett,
  • Fiona McDonald,
  • Clifford Robinson,
  • Anna-Maria Shiarli,
  • Michael W. Straza,
  • Joost J. C. Verhoeff,
  • Maria Werner-Wasik,
  • Gregory Vlacich,
  • David Cobben,
  • David Cobben

DOI
https://doi.org/10.3389/fonc.2021.617681
Journal volume & issue
Vol. 11

Abstract

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Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest technological advance which may help with achieving this aim. The majority of MRgRT treatments delivered to date have been stereotactic body radiation therapy (SBRT) based and include the treatment of (ultra-) central tumors. However, there is a move to also implement MRgRT as curative-intent treatment for patients with inoperable locally advanced NSCLC. This paper presents the initial clinical experience of using the two commercially available systems to date: the ViewRay MRIdian and Elekta Unity. The challenges and potential solutions associated with MRgRT in lung cancer will also be highlighted.

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