Life (Oct 2024)

Investigating the Hepatic Response to Orlistat and White Tea in Rats on a High-Fat Diet

  • Serpil Ciftel,
  • Aleksandra Klisic,
  • Enver Ciftel,
  • Tolga Mercantepe,
  • Adnan Yilmaz,
  • Sedat Ciftel,
  • Esra Pinarbas,
  • Merve Nur Toraman,
  • Filiz Mercantepe

DOI
https://doi.org/10.3390/life14101283
Journal volume & issue
Vol. 14, no. 10
p. 1283

Abstract

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High-fat diets have detrimental health impacts that increase the likelihood of developing obesity and metabolic syndrome. This study aimed to examine the potential antioxidant and anti-inflammatory effects of orlistat and white tea in rats fed a high-fat diet. Thirty-two rats were randomized into four groups: control (standard diet), HFD (high-fat diet), HFD+Orlistat (high-fat diet+orlistat), and HFD+WT (high-fat diet+white tea extract). A significant increase in malondialdehyde (MDA) levels and a decrease in total thiol (TT) levels were detected in the HFD group (p p p p = 0.001). Immunohistochemical examinations of nuclear factor-kappa B (NF-kB/p65) revealed that compared with the HFD, orlistat and white tea reduced immunopositivity (p = 0.001). White tea decreases lipid peroxidation and oxidative stress. Both white tea and orlistat decreased fat formation and inflammation in the liver and regulated inflammation by reducing Nf-kB positivity. Nevertheless, further research is needed to assess their impact on human subjects.

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