BMC Nephrology (Jun 2012)

A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood

  • Tsuji Kenji,
  • Uchida Haruhito,
  • Ono Tetsuichirou,
  • Inoue Tatsuyuki,
  • Shinagawa Katsuji,
  • Kitamura Shinji,
  • Maeshima Yohei,
  • Sugiyama Hitoshi,
  • Makino Hirofumi

DOI
https://doi.org/10.1186/1471-2369-13-46
Journal volume & issue
Vol. 13, no. 1
p. 46

Abstract

Read online

Abstract Background Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause. Case presentation We report a 36-year-old man who had suffered membranoproliferative glomerulonephritis (MPGN) in his childhood, later diagnosed with CVID at 35 years of age. He presented at our hospital with signs of proteinuria. A renal biopsy revealed he suffered from focal segmental glomerulosclerosis (FSGS), possibly due to obesity and hypertension, not CVID - associated MPGN. Conclusion This is the first case report of FSGS in a CVID patient. In this case, we have to pay attention not only to the treatment of obesity and hypertension for FSGS but also to the recurrence of immune-complex glomerulonephritis such as MPGN, in case of the restoration of hypogammaglobulinemia.

Keywords