Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation

Aleksandra Saletra-Bielińska; Katarzyna Kosińska-Kaczyńska; Iwona Szymusik; Bartosz Kaczyński; Robert Brawura-Biskupski-Samaha; Szymon Kozłowski; Patrycja Jarmużek; Izabela Walasik; Mirosław Wielgoś

doi:10.3390/jcm9072099

Journal of Clinical Medicine (Jul 2020)

Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation

Aleksandra Saletra-Bielińska,
Katarzyna Kosińska-Kaczyńska,
Iwona Szymusik,
Bartosz Kaczyński,
Robert Brawura-Biskupski-Samaha,
Szymon Kozłowski,
Patrycja Jarmużek,
Izabela Walasik,
Mirosław Wielgoś

Affiliations

Aleksandra Saletra-Bielińska: Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Katarzyna Kosińska-Kaczyńska: Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Iwona Szymusik: Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Bartosz Kaczyński: Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 02-091 Warsaw, Poland
Robert Brawura-Biskupski-Samaha: Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Szymon Kozłowski: University Center for Woman and Newborn Health of the Medical University of Warsaw, 02-015 Warsaw, Poland
Patrycja Jarmużek: Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Izabela Walasik: Students Scientific Association at the 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland
Mirosław Wielgoś: Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland

DOI: https://doi.org/10.3390/jcm9072099
Journal volume & issue: Vol. 9, no. 7
p. 2099

Abstract

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In twin gestation, the relationship between pregnancy associated plasma protein (PAPP-A) and perinatal outcome is unclear. The aim of the study was to determine if low and high concentrations of PAPP-A in the first trimester are related to perinatal outcome in twins. A retrospective study was conducted. Medical data of women in twin pregnancies who delivered between 2013 and 2018 were analyzed. PAPP-A concentrations were measured between 10 + 0 and 13 + 6 weeks. The associations between low (90th percentile) values of PAPP-A and pregnancy complications were analyzed. A total of 304 patients were included. PAPP-A 90th percentile and delivery 90th percentile was related to high risk of intrauterine fetal demise (OR 10; 95% CI 2.4–42.5). Both low and high PAPP-A concentrations seem to be related to pregnancy outcome. Further research is needed to investigate evaluation of risk of pregnancy complications according to PAPP-A concentrations as a continuous variable.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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