Nature Communications (Nov 2021)

Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase

  • F. Kolbe,
  • S. Safarian,
  • Ż. Piórek,
  • S. Welsch,
  • H. Müller,
  • H. Michel

DOI
https://doi.org/10.1038/s41467-021-27174-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.