Zdorovʹe Rebenka (Sep 2019)
Pharmacological effect on biofilm dispersion. Derivatives of the diffusible signal factor family
Abstract
The scientific review deals with the role of representatives of the family of the diffusible signal factor (DSF), which are cis-2-decenoic acid, in the process of dispersing biofilms of pathogenic bacteria. For writing the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka. The family of the diffusible signal factor, the mechanisms for the reception of its molecular representatives, the transduction pathways and the biological effects caused by their action are characterized. A two-component system of sensory kinase RpfC/regulator RpfG, which transmits DSF-associated signals, has been identified in various bacterial pathogens, including Xanthomonas, Enterobacter, Thiobacillus, Xylella, Serratia, Leptospirillum, Stenotrophomonas, Burkholderia, Achromobacter, Yersinia, Methylobacillus, Pantoea, and Cronobacter. The intracellular sensory protein RpfR represents the DSF receptor pathway and has been identified in Burkholderia bacteria. The membrane-associated histidine kinase PA1396 carries out the reconnaissance of DSF or BDSF by the bacteria Pseudomonas aeruginosa. It is shown that the virulence level of various bacterial pathogens can be modulated by structural analogues of a diffusible signal factor. It is shown that the medicines developed on the basis of diffusible signal factors and influencing the transduction mechanisms of the intra-bacterial signal caused by them will allow solving the therapeutic task of overcoming the resistance of recurrent and chronic infectious-inflammatory diseases of the respiratory tract. A more pronounced decrease in viability formed by antibiotic-resistant bacteria Staphylococcus aureus biofilms is observed when cis-2-decenoic acid is used in combination with antibacterial agents.
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