IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Christoph Jandl; Sue M. Liu; Pablo F. Cañete; Joanna Warren; William E. Hughes; Alexis Vogelzang; Kylie Webster; Maria E. Craig; Gulbu Uzel; Alexander Dent; Polina Stepensky; Bärbel Keller; Klaus Warnatz; Jonathan Sprent; Cecile King

doi:10.1038/ncomms14647

Nature Communications (Mar 2017)

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Christoph Jandl,
Sue M. Liu,
Pablo F. Cañete,
Joanna Warren,
William E. Hughes,
Alexis Vogelzang,
Kylie Webster,
Maria E. Craig,
Gulbu Uzel,
Alexander Dent,
Polina Stepensky,
Bärbel Keller,
Klaus Warnatz,
Jonathan Sprent,
Cecile King

Affiliations

Christoph Jandl: Department of Immunology, Garvan Institute of Medical Research
Sue M. Liu: Department of Immunology, Garvan Institute of Medical Research
Pablo F. Cañete: Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University
Joanna Warren: Department of Immunology, Garvan Institute of Medical Research
William E. Hughes: Department of Immunology, Garvan Institute of Medical Research
Alexis Vogelzang: Department of Immunology, Garvan Institute of Medical Research
Kylie Webster: Department of Immunology, Garvan Institute of Medical Research
Maria E. Craig: Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Sydney
Gulbu Uzel: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Alexander Dent: Department of Microbiology and Immunology, Indiana University School of Medicine
Polina Stepensky: Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Hebrew University Hospital, Kiryat Hadassah
Bärbel Keller: Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg
Klaus Warnatz: Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg
Jonathan Sprent: Department of Immunology, Garvan Institute of Medical Research
Cecile King: Department of Immunology, Garvan Institute of Medical Research

DOI: https://doi.org/10.1038/ncomms14647
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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