STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA

Abstract

The goal of present study was to perform a comparative evaluation of cytokine levels in blood of 123 patients with uncomplicated influenza versus a group of cases complicated by subsequent pneumonia. Higher levels of TNFα, IL-10, IL-6, IL-8 and lower levels of IFNγ were found in blood serum of those patients who developed pneumonia during acute phase of influenza. We have revealed a correlation between the severity and duration of symptoms of both uncomplicated and pneumonia-conplicated flu, and serum concentrations of proinflammatory (TNFα, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-1rа, и IL-10), as well as with indexes of interferon profile (antiIFNα, IFNα и IFNγ) in the patients.

Keywords

• influenza
• pneumonia
• cytokines
• correlation