Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Abstract

While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.

Keywords

• genomic instability
• chromatin
• mitochondrial homeostasis
• metabolism
• cancer