Nature Communications (Jan 2019)
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
- Samuel E. Jones,
- Jacqueline M. Lane,
- Andrew R. Wood,
- Vincent T. van Hees,
- Jessica Tyrrell,
- Robin N. Beaumont,
- Aaron R. Jeffries,
- Hassan S. Dashti,
- Melvyn Hillsdon,
- Katherine S. Ruth,
- Marcus A. Tuke,
- Hanieh Yaghootkar,
- Seth A. Sharp,
- Yingjie Jie,
- William D. Thompson,
- Jamie W. Harrison,
- Amy Dawes,
- Enda M. Byrne,
- Henning Tiemeier,
- Karla V. Allebrandt,
- Jack Bowden,
- David W. Ray,
- Rachel M. Freathy,
- Anna Murray,
- Diego R. Mazzotti,
- Philip R. Gehrman,
- Debbie A. Lawlor,
- Timothy M. Frayling,
- Martin K. Rutter,
- David A. Hinds,
- Richa Saxena,
- Michael N. Weedon
Affiliations
- Samuel E. Jones
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Jacqueline M. Lane
- Center for Genomic Medicine, Massachusetts General Hospital
- Andrew R. Wood
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Vincent T. van Hees
- Netherlands eScience Center
- Jessica Tyrrell
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Robin N. Beaumont
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Aaron R. Jeffries
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Hassan S. Dashti
- Center for Genomic Medicine, Massachusetts General Hospital
- Melvyn Hillsdon
- Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter
- Katherine S. Ruth
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Marcus A. Tuke
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Hanieh Yaghootkar
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Seth A. Sharp
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Yingjie Jie
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- William D. Thompson
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Jamie W. Harrison
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Amy Dawes
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Enda M. Byrne
- The University of Queensland, Institute for Molecular Bioscience
- Henning Tiemeier
- Department of Epidemiology, Erasmus Medical Center
- Karla V. Allebrandt
- Department of Translational Informatics, Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst
- Jack Bowden
- MRC Integrative Epidemiology Unit at the University of Bristol
- David W. Ray
- Faculty of Biology, Medicine and Health, University of Manchester
- Rachel M. Freathy
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Anna Murray
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Diego R. Mazzotti
- Center for Sleep and Circadian Neurobiology, University of Pennsylvania
- Philip R. Gehrman
- Perelman School of Medicine of the University of Pennsylvania
- Debbie A. Lawlor
- MRC Integrative Epidemiology Unit at the University of Bristol
- Timothy M. Frayling
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- Martin K. Rutter
- Faculty of Biology, Medicine and Health, University of Manchester
- David A. Hinds
- 23andMe Inc.
- Richa Saxena
- Center for Genomic Medicine, Massachusetts General Hospital
- Michael N. Weedon
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital
- DOI
- https://doi.org/10.1038/s41467-018-08259-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
GWAS have previously found 24 genomic loci associated with chronotype, an individual’s preference for early or late sleep timing. Here, the authors identify 327 additional loci in a sample of 697,828 individuals and further explore the relationships of chronotype with metabolic and psychiatric diseases.
