Frontiers in Immunology (Oct 2024)

Towards personalized vaccines

  • Davide Montin,
  • Veronica Santilli,
  • Alessandra Beni,
  • Giorgio Costagliola,
  • Baldassarre Martire,
  • Maria Felicia Mastrototaro,
  • Giorgio Ottaviano,
  • Caterina Rizzo,
  • Mayla Sgrulletti,
  • Mayla Sgrulletti,
  • Michele Miraglia Del Giudice,
  • Viviana Moschese

DOI
https://doi.org/10.3389/fimmu.2024.1436108
Journal volume & issue
Vol. 15

Abstract

Read online

The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored to individual genetic and immunological profiles. Integrating insights from genomics, transcriptomics, proteomics, and immunology, personalized vaccines offer the promise of enhanced efficacy and safety, revolutionizing the field of vaccinology. However, the development of personalized vaccines presents multifaceted challenges, including technical, ethical, economic, and regulatory considerations. Addressing these challenges is essential to ensure equitable access and safety of personalized vaccination strategies. Despite these hurdles, the potential of personalized vaccines to optimize responses and mitigate disease burden underscores the significance of ongoing research and collaboration in advancing precision medicine in immunization.

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