Nature Communications (Nov 2021)

NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates

  • Anthony G. Boghdadi,
  • Joshua Spurrier,
  • Leon Teo,
  • Mingfeng Li,
  • Mario Skarica,
  • Benjamin Cao,
  • William C. Kwan,
  • Tobias D. Merson,
  • Susan K. Nilsson,
  • Nenad Sestan,
  • Stephen M. Strittmatter,
  • James A. Bourne

DOI
https://doi.org/10.1038/s41467-021-27245-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Astrocytes are important players in ischemic stroke. Here, the authors use single nuclei transcriptomics to characterise marmoset astrocytes following brain injury. At functional level, they show that NogoAexpressing astrocytes limit macrophage infiltration.