Metabolic and hemostatic parameters in patients with type 2 diabetes and hypothyroidism

Abstract

To identify hemostatic and metabolic abnormalities in patients with hypothyroidism of varying severity and duration and possible modifying effects of chronic hyperglycemia on the investigated parameters comprehensive analysis of the parameters of metabolism, platelet and plasma hemostasis in 69 patients with hypothyroidism and 36 patients having hypothyroidism and diabetes mellitus (DM) has been performed. Decompensated hypothyroidism regardless of disease duration and presence of complications is accompanied by platelets hyperfunction. In subcompensated hypothyroidism the aggregation activity was not changed. The combination of type 2 diabetes in patients with decompensated and subcompensated hypothyroidism is accompanied by platelets activation, hypertriglyceridemia, increased platelets average volume and shortening of APTT.

Keywords

• type 2 diabetes
• subcompensated and uncompensated hypothyroidism
• platelet hemostasis