Cancers (Aug 2022)
An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves
- Oskar Wysocki,
- Cong Zhou,
- Jacobo Rogado,
- Prerana Huddar,
- Rohan Shotton,
- Ann Tivey,
- Laurence Albiges,
- Angelos Angelakas,
- Dirk Arnold,
- Theingi Aung,
- Kathryn Banfill,
- Mark Baxter,
- Fabrice Barlesi,
- Arnaud Bayle,
- Benjamin Besse,
- Talvinder Bhogal,
- Hayley Boyce,
- Fiona Britton,
- Antonio Calles,
- Luis Castelo-Branco,
- Ellen Copson,
- Adina Croitoru,
- Sourbha S. Dani,
- Elena Dickens,
- Leonie Eastlake,
- Paul Fitzpatrick,
- Stephanie Foulon,
- Henrik Frederiksen,
- Sarju Ganatra,
- Spyridon Gennatas,
- Andreas Glenthøj,
- Fabio Gomes,
- Donna M. Graham,
- Christina Hague,
- Kevin Harrington,
- Michelle Harrison,
- Laura Horsley,
- Richard Hoskins,
- Zoe Hudson,
- Lasse H. Jakobsen,
- Nalinie Joharatnam-Hogan,
- Sam Khan,
- Umair T. Khan,
- Khurum Khan,
- Alexandra Lewis,
- Christophe Massard,
- Alec Maynard,
- Hayley McKenzie,
- Olivier Michielin,
- Anne C. Mosenthal,
- Berta Obispo,
- Carlo Palmieri,
- Rushin Patel,
- George Pentheroudakis,
- Solange Peters,
- Kimberly Rieger-Christ,
- Timothy Robinson,
- Emanuela Romano,
- Michael Rowe,
- Marina Sekacheva,
- Roseleen Sheehan,
- Alexander Stockdale,
- Anne Thomas,
- Lance Turtle,
- David Viñal,
- Jamie Weaver,
- Sophie Williams,
- Caroline Wilson,
- Caroline Dive,
- Donal Landers,
- Timothy Cooksley,
- André Freitas,
- Anne C. Armstrong,
- Rebecca J. Lee,
- on behalf of the ESMO Co-Care
Affiliations
- Oskar Wysocki
- Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK
- Cong Zhou
- Cancer Research UK Manchester Institute, Cancer Biomarker Centre, The University of Manchester, Al-derley Park, Macclesfield SK10 4TG, UK
- Jacobo Rogado
- Department of Medical Oncology, Hospital Universitario Infanta Leonor, Av. Gran Vía del Este, 80, 28031 Madrid, Spain
- Prerana Huddar
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Rohan Shotton
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Ann Tivey
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Laurence Albiges
- Department of Medical Oncology, Gustave Roussy, 94805 Villejuif, France
- Angelos Angelakas
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Dirk Arnold
- Department of Oncology, Haematology and Palliative Care, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763 Hamburg, Germany
- Theingi Aung
- Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Kathryn Banfill
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Mark Baxter
- Division of Molecular and Clinical Medicine, Ninewells School of Medicine, University of Dundee, Dundee DD2 1SY, UK
- Fabrice Barlesi
- Department of Medical Oncology, Gustave Roussy, 94805 Villejuif, France
- Arnaud Bayle
- Drug Development Department (DITEP), Gustave Roussy—Cancer Campus, 94805 Villejuif, France
- Benjamin Besse
- Drug Development Department (DITEP), Gustave Roussy—Cancer Campus, 94805 Villejuif, France
- Talvinder Bhogal
- Department of Medical Oncology, The Clatterbridge Cancer Centre NHS Foundation Trust, 65 Pembroke Place, Liverpool L7 8YA, UK
- Hayley Boyce
- Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Fiona Britton
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Antonio Calles
- Department of Medical Oncology, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007 Madrid, Spain
- Luis Castelo-Branco
- ESMO-CoCARE Steering Committee, European Society for Medical Oncology, Via Ginevra 4, 6900 Lugano, Switzerland
- Ellen Copson
- Cancer Sciences Academic Unit, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK
- Adina Croitoru
- Medical Oncology Department, Fundeni Clinical Institute, 258, Fundeni Str., 022238 București, Romania
- Sourbha S. Dani
- Department of Cardiology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA
- Elena Dickens
- Oncology Department, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
- Leonie Eastlake
- Department of Medical Oncology, University Hospitals Plymouth NHS Trust, Derriford Road, Plymouth PL6 8DH, Devon, UK
- Paul Fitzpatrick
- Digital Experimental Cancer Medicine Team, Cancer Biomarker Centre, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK
- Stephanie Foulon
- Oncostat (CESP U1018 INSERM), Labeled Ligue Contre le Cancer, University Paris-Saclay, 94805 Villejuif, France
- Henrik Frederiksen
- Department of Haematology, Odense University Hospital, 5000 Odense, Denmark
- Sarju Ganatra
- Department of Cardiology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA
- Spyridon Gennatas
- Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK
- Andreas Glenthøj
- Department of Haematology, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, Denmark
- Fabio Gomes
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Donna M. Graham
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Christina Hague
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Kevin Harrington
- Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK
- Michelle Harrison
- Ninewells Hospital and Medical School, Dundee DD2 1SG, UK
- Laura Horsley
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Richard Hoskins
- Research IT, University of Manchester, Oxford Road, Manchester M13 9PL, UK
- Zoe Hudson
- Bristol Haematology and Oncology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8ED, UK
- Lasse H. Jakobsen
- Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark
- Nalinie Joharatnam-Hogan
- Department of Medical Oncology, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK
- Sam Khan
- Oncology Department, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
- Umair T. Khan
- Department of Medical Oncology, The Clatterbridge Cancer Centre NHS Foundation Trust, 65 Pembroke Place, Liverpool L7 8YA, UK
- Khurum Khan
- Department of Medical Oncology, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK
- Alexandra Lewis
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Christophe Massard
- Drug Development Department (DITEP), Gustave Roussy—Cancer Campus, 94805 Villejuif, France
- Alec Maynard
- Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Hayley McKenzie
- Cancer Sciences Academic Unit, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK
- Olivier Michielin
- Department of Oncology, Melanoma Clinic, Swiss Institute of Bioinformatics, Quartier Sorge—Batiment Amphipole, 1015 Lausanne, Switzerland
- Anne C. Mosenthal
- Department of Cardiology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA
- Berta Obispo
- Department of Medical Oncology, Hospital Universitario Infanta Leonor, Av. Gran Vía del Este, 80, 28031 Madrid, Spain
- Carlo Palmieri
- Department of Medical Oncology, The Clatterbridge Cancer Centre NHS Foundation Trust, 65 Pembroke Place, Liverpool L7 8YA, UK
- Rushin Patel
- Department of Cardiology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA
- George Pentheroudakis
- ESMO-CoCARE Steering Committee, European Society for Medical Oncology, Via Ginevra 4, 6900 Lugano, Switzerland
- Solange Peters
- ESMO-CoCARE Steering Committee, European Society for Medical Oncology, Via Ginevra 4, 6900 Lugano, Switzerland
- Kimberly Rieger-Christ
- Department of Cardiology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA
- Timothy Robinson
- Bristol Haematology and Oncology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8ED, UK
- Emanuela Romano
- Department of Oncology, Institut Curie, PSL Research University, Office 2A-5, 26, Rue d’Ulm, 75005 Paris, France
- Michael Rowe
- Sunrise Centre, Royal Cornwall Hospitals NHS Trust, Truro TR1 3LJ, Cornwall, UK
- Marina Sekacheva
- World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University, 119991 Moscow, Russia
- Roseleen Sheehan
- Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Alexander Stockdale
- Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, 3Z Link, Prescot Street, Liverpool L7 8XP, UK
- Anne Thomas
- Oncology Department, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
- Lance Turtle
- Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, 3Z Link, Prescot Street, Liverpool L7 8XP, UK
- David Viñal
- Department of Medical Oncology, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
- Jamie Weaver
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Sophie Williams
- Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Caroline Wilson
- Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Caroline Dive
- Cancer Research UK Manchester Institute, Cancer Biomarker Centre, The University of Manchester, Al-derley Park, Macclesfield SK10 4TG, UK
- Donal Landers
- Digital Experimental Cancer Medicine Team, Cancer Biomarker Centre, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK
- Timothy Cooksley
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- André Freitas
- Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK
- Anne C. Armstrong
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- Rebecca J. Lee
- Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
- on behalf of the ESMO Co-Care
- DOI
- https://doi.org/10.3390/cancers14163931
- Journal volume & issue
-
Vol. 14,
no. 16
p. 3931
Abstract
Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only). The performance of CORONET was evaluated on 258, 48, and 54 patients for each wave, respectively. We found that mortality rates were reduced in subsequent waves. The majority of patients were vaccinated in wave 4, and 94% were treated with steroids if they required oxygen. The stages of cancer and the median ages of patients significantly differed, but features associated with worse COVID-19 outcomes remained predictive and did not differ between waves. The CORONET tool performed well in all waves, with scores in an area under the curve (AUC) of >0.72. We concluded that patients with cancer who present to hospital with COVID-19 have similar features of severity, which remain discriminatory despite differences in variants and vaccination status. Survival improved following the first wave of the pandemic, which may be associated with vaccination and the increased steroid use in those patients requiring oxygen. The CORONET model demonstrated good performance, independent of the SARS-CoV-2 variants.
Keywords