Genetic variation and RNA structure regulate microRNA biogenesis

Noemi Fernandez; Ross A. Cordiner; Robert S. Young; Nele Hug; Sara Macias; Javier F. Cáceres

doi:10.1038/ncomms15114

Nature Communications (May 2017)

Genetic variation and RNA structure regulate microRNA biogenesis

Noemi Fernandez,
Ross A. Cordiner,
Robert S. Young,
Nele Hug,
Sara Macias,
Javier F. Cáceres

Affiliations

Noemi Fernandez: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Genome Regulation Section, Western General Hospital, University of Edinburgh
Ross A. Cordiner: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Genome Regulation Section, Western General Hospital, University of Edinburgh
Robert S. Young: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Genome Regulation Section, Western General Hospital, University of Edinburgh
Nele Hug: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Genome Regulation Section, Western General Hospital, University of Edinburgh
Sara Macias: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Genome Regulation Section, Western General Hospital, University of Edinburgh
Javier F. Cáceres: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Genome Regulation Section, Western General Hospital, University of Edinburgh

DOI: https://doi.org/10.1038/ncomms15114
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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