Nature Communications (May 2016)
Phosphatidylserine exposure is required for ADAM17 sheddase function
- Anselm Sommer,
- Felix Kordowski,
- Joscha Büch,
- Thorsten Maretzky,
- Astrid Evers,
- Jörg Andrä,
- Stefan Düsterhöft,
- Matthias Michalek,
- Inken Lorenzen,
- Prasath Somasundaram,
- Andreas Tholey,
- Frank D. Sönnichsen,
- Karl Kunzelmann,
- Lena Heinbockel,
- Christian Nehls,
- Thomas Gutsmann,
- Joachim Grötzinger,
- Sucharit Bhakdi,
- Karina Reiss
Affiliations
- Anselm Sommer
- Department of Dermatology, University of Kiel
- Felix Kordowski
- Department of Dermatology, University of Kiel
- Joscha Büch
- Department of Dermatology, University of Kiel
- Thorsten Maretzky
- Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University
- Astrid Evers
- Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University
- Jörg Andrä
- Hamburg University of Applied Science
- Stefan Düsterhöft
- Institute of Biochemistry, University of Kiel
- Matthias Michalek
- Institute of Biochemistry, University of Kiel
- Inken Lorenzen
- Institute of Biochemistry, University of Kiel
- Prasath Somasundaram
- Division of Systematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, University of Kiel
- Andreas Tholey
- Division of Systematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, University of Kiel
- Frank D. Sönnichsen
- Otto Diels Institute for Organic Chemistry, University of Kiel
- Karl Kunzelmann
- Physiological Institute, University of Regensburg
- Lena Heinbockel
- Forschungszentrum Borstel, Leibniz-Zentrum für Medizin and Biowissenschaften
- Christian Nehls
- Forschungszentrum Borstel, Leibniz-Zentrum für Medizin and Biowissenschaften
- Thomas Gutsmann
- Forschungszentrum Borstel, Leibniz-Zentrum für Medizin and Biowissenschaften
- Joachim Grötzinger
- Institute of Biochemistry, University of Kiel
- Sucharit Bhakdi
- Department of Dermatology, University of Kiel
- Karina Reiss
- Department of Dermatology, University of Kiel
- DOI
- https://doi.org/10.1038/ncomms11523
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates.
