Frontiers in Chemistry (Jul 2021)

A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging

  • Mingzhou Wu,
  • Mingzhou Wu,
  • Shuqing He,
  • Xin Hu,
  • Jingqin Chen,
  • Enna Ha,
  • Fujin Ai,
  • Tao Ji,
  • Junqing Hu,
  • Shuangchen Ruan,
  • Shuangchen Ruan

DOI
https://doi.org/10.3389/fchem.2021.695511
Journal volume & issue
Vol. 9

Abstract

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Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu7.2S4/5MoS2 composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu7.2S4/5MoS2 exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal–chemodynamic–photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu7.2S4/5MoS2 shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu7.2S4/5MoS2 composite nanoflowers as photo/H2O2-responsive therapeutic agents against tumors.

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