Free-radical oxidation condition of the patients with infiltrative pulmonary tuberculosis depending on the pathogenetic treatment method

Abstract

Objective: to assess the impact of the methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide medication on the free-radical oxidation processes and the possibility of its use as a multifunctional mean of pathogenetic tuberculosis therapy. Material and methods: a comparative analysis of treatment efficiency, clinic-laboratory data, and free-radical oxidation indices of 50 patients with active pulmonary tuberculosis, which obtained methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide and a standard pathogenetic therapy, was carried out. Results: a decrease in the frequency and severity of destruction of lung tissue, the cessation of bacterial release, rapid resolution of infiltration in the lung tissue, which was accompanied by the normalization of the parameters of the antioxidant protection system, was revealed under the influence of methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide. Conclusions: the use of methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide as a pathogenetic medication for patients, who received antituberculosis treatment, results in substantial positive clinic-laboratory dynamics, increase of treatment efficiency, and normalization of free-radical oxidation indices in comparison with those, who received standard pathogenetic therapy.

Keywords

• tuberculosis
• pathogenetic therapy