Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module

Abstract

Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module, which the precursors were stored. The productions were purified by semi-HPLC and solid phase extraction (SPE) to get the final radiopharmaceuticals. There are four carbon-11 radiopharmaceuticals were synthesized with the method, which it were 11C-Raclopride,11C-PIB,11C-DASB and 11C-PK11195,and synthesis yields were （38.2±4.5）% (n=10），（68.4±3.2）% (n=12), （52.4±5.5）%(n=4）and （45.6±7.1）% (n=8）respectively. All productions radiochemical purity were over 95%. Assembled the methyl iodide module with PET-MV-2-F, which it had semi-HPLC, we can synthesize most carbon-11 radiopharmaceuticals for clinical used.

Keywords

• synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals