Nature Communications (Apr 2018)

Matriptase-2 deficiency protects from obesity by modulating iron homeostasis

  • Alicia R. Folgueras,
  • Sandra Freitas-Rodríguez,
  • Andrew J. Ramsay,
  • Cecilia Garabaya,
  • Francisco Rodríguez,
  • Gloria Velasco,
  • Carlos López-Otín

DOI
https://doi.org/10.1038/s41467-018-03853-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Iron homeostasis dysfunctions have been associated with several metabolic disorders including obesity, steatosis and diabetes. Here the authors demonstrate that the hepcidin repressor matriptase-2 regulates adiposity and its deficiency protects mice against obesity and promotes lipolysis.