Extra-coding RNAs regulate neuronal DNA methylation dynamics

Katherine E. Savell; Nancy V. N. Gallus; Rhiana C. Simon; Jordan A. Brown; Jasmin S. Revanna; Mary Katherine Osborn; Esther Y. Song; John J. O’Malley; Christian T. Stackhouse; Allison Norvil; Humaira Gowher; J. David Sweatt; Jeremy J. Day

doi:10.1038/ncomms12091

Nature Communications (Jul 2016)

Extra-coding RNAs regulate neuronal DNA methylation dynamics

Katherine E. Savell,
Nancy V. N. Gallus,
Rhiana C. Simon,
Jordan A. Brown,
Jasmin S. Revanna,
Mary Katherine Osborn,
Esther Y. Song,
John J. O’Malley,
Christian T. Stackhouse,
Allison Norvil,
Humaira Gowher,
J. David Sweatt,
Jeremy J. Day

Affiliations

Katherine E. Savell: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Nancy V. N. Gallus: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Rhiana C. Simon: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Jordan A. Brown: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Jasmin S. Revanna: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Mary Katherine Osborn: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Esther Y. Song: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
John J. O’Malley: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Christian T. Stackhouse: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Allison Norvil: Department of Biochemistry, Purdue University
Humaira Gowher: Department of Biochemistry, Purdue University
J. David Sweatt: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham
Jeremy J. Day: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/ncomms12091
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

DNA methylation in the brain is a dynamic process, but gene-specific regulation of this process is poorly understood. Here, Day and colleagues show that extra-coding RNAs interact with DNA methyltransferases and regulate neuronal DNA methylation to control gene expression in locus-specific manner in neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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