Nature Communications (Nov 2022)

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

  • Chenxi Cao,
  • Yuanyuan Shi,
  • Xin Zhang,
  • Qi Li,
  • Jiahao Zhang,
  • Fengyuan Zhao,
  • Qingyang Meng,
  • Wenli Dai,
  • Zhenlong Liu,
  • Wenqiang Yan,
  • Xiaoning Duan,
  • Jiying Zhang,
  • Xin Fu,
  • Jin Cheng,
  • Xiaoqing Hu,
  • Yingfang Ao

DOI
https://doi.org/10.1038/s41467-022-34830-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling, implicating the cholesterol-LRP3-SDC4 axis in osteoarthritic cartilage degeneration.