Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-ones

Abstract

Interaction of methyl esters of acylpyruvic acides with mixture of aromatic aldehyde and tryptamine or 5-methoxytryptamine leads to 5-aryl-4-acyl-3-hydroxy-1-[2-(3-indolil)-ethyl)-2,5-dihydropyrrol-2-ones (I). The compounds (I) were transformed to 3,4-diaryl-1,4,5,6-tetrahydro-6-oxo-5-(2-(3-indolil)-ethyl)pyrrolo[3,4-c]pyrazoles (II) by reaction with hydrazine-hydrate. The structure of received compounds is established. The analgetical activity of compounds (I б-е) and (II) is investigated.

Keywords

• триптамин
• эфиры ацилпировиноградных кислот
• 3-гидрокси-2,5-дигидропиррол-2-оны
• анальгетическая активность