Communications Biology (Jan 2022)
Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection
- Flora Mikaeloff,
- Sara Svensson Akusjärvi,
- George Mondinde Ikomey,
- Shuba Krishnan,
- Maike Sperk,
- Soham Gupta,
- Gustavo Daniel Vega Magdaleno,
- Alejandra Escós,
- Emilia Lyonga,
- Marie Claire Okomo,
- Claude Tayou Tagne,
- Hemalatha Babu,
- Christian L. Lorson,
- Ákos Végvári,
- Akhil C. Banerjea,
- Julianna Kele,
- Luke Elizabeth Hanna,
- Kamal Singh,
- João Pedro de Magalhães,
- Rui Benfeitas,
- Ujjwal Neogi
Affiliations
- Flora Mikaeloff
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- Sara Svensson Akusjärvi
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- George Mondinde Ikomey
- Center for the Study and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1
- Shuba Krishnan
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- Maike Sperk
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- Soham Gupta
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- Gustavo Daniel Vega Magdaleno
- Integrative Genomics of Ageing Group, Institute of Life Course and Medical Sciences, University of Liverpool
- Alejandra Escós
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- Emilia Lyonga
- Center for the Study and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1
- Marie Claire Okomo
- Center for the Study and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1
- Claude Tayou Tagne
- Department of Microbiology, Haematology, Parasitology and Infectious Disease, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1
- Hemalatha Babu
- Department of HIV/AIDS, National Institute for Research in Tuberculosis, ICMR
- Christian L. Lorson
- Christopher S. Bond Life Sciences Center, University of Missouri
- Ákos Végvári
- Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Akhil C. Banerjea
- National Institute of Immunology, Aruna Asaf Ali Marg
- Julianna Kele
- Department of Physiology and Pharmacology, Neurovascular Biology and Health, Karolinska Institutet
- Luke Elizabeth Hanna
- Department of HIV/AIDS, National Institute for Research in Tuberculosis, ICMR
- Kamal Singh
- Christopher S. Bond Life Sciences Center, University of Missouri
- João Pedro de Magalhães
- Integrative Genomics of Ageing Group, Institute of Life Course and Medical Sciences, University of Liverpool
- Rui Benfeitas
- National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Ujjwal Neogi
- The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg
- DOI
- https://doi.org/10.1038/s42003-021-02985-3
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
Mikaeloff et al. use untargeted and targeted LC-MS/MS-based plasma metabolic profiling to discover dysregulated metabolism including that of glutaminolysis in individuals living with HIV. Furthermore, decreased levels of neurosteroids were detected suggesting a potential connection between HIV and neurological impairment.
