Nature Communications (Jun 2021)

Sugar phosphate activation of the stress sensor eIF2B

  • Qi Hao,
  • Jin-Mi Heo,
  • Boguslaw P. Nocek,
  • Kevin G. Hicks,
  • Vincent S. Stoll,
  • Clint Remarcik,
  • Sean Hackett,
  • Lauren LeBon,
  • Rinku Jain,
  • Dan Eaton,
  • Jared Rutter,
  • Yao Liang Wong,
  • Carmela Sidrauski

DOI
https://doi.org/10.1038/s41467-021-23836-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.