Evaluation of the VKORC 1 and CYP2C9 Gene Polymorphisms and Their Effects on the Emergency Complications in the Patients Using Warfarin

Abstract

Aim: We aimed to evaluate the effects of genetic polymorphisms on the frequency of application to the emergency service and on the complications with use of warfarin in this study.Materials and Methods: Seventy patients were included in the study. Two groups were composed: one group of 40 patients who used warfarin and with international normalized ratios (INRs) ≥3.5 IU and a second group of 30 control group patients with normal INR levels. Blood samples were examined through the warfarin dosage sensitivity test.Results: VKORC 1 heterozygote type AG was the most frequently seen allele in 17 of the haplotype patients (42.5%), in 12 of the control group patients (40%), in 21 of the CYP2C9 *1/*1 patients (52.5%), and in 17 of the CYP2C9 *1/*1 control group patients. No statistically significant difference was identified between the groups (p>0.05). No statistically significant relationship was established as regards the frequency of emergency service visits and bleeding complications with CYP2C9 and VKORC 1 genes.Conclusion: The most common haplotypes VKORC 1 heterozygote type AG and CYP2C9 *1/*1. No relationship was identified between INR levels and VKORC 1 and CYP2C9 haplotypes. These genes have no effect on bleeding and frequent applications of emergency service.

Keywords

• Warfarin
• gene polymorphism
• emergency service
• VKORC 1
• CYP2C9