Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA

Déborah Bouvier; Juliette Ferrand; Odile Chevallier; Michelle T. Paulsen; Mats Ljungman; Sophie E. Polo

doi:10.1038/s41467-021-24153-1

Nature Communications (Jun 2021)

Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA

Déborah Bouvier,
Juliette Ferrand,
Odile Chevallier,
Michelle T. Paulsen,
Mats Ljungman,
Sophie E. Polo

Affiliations

Déborah Bouvier: Epigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris
Juliette Ferrand: Epigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris
Odile Chevallier: Epigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris
Michelle T. Paulsen: Department of Radiation Oncology, University of Michigan
Mats Ljungman: Department of Radiation Oncology, University of Michigan
Sophie E. Polo: Epigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris

DOI: https://doi.org/10.1038/s41467-021-24153-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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How gene expression reactivation is promoted following DNA damage is not yet clear. Here, the authors identify a role for the human histone chaperone complex HIRA in transcription restart following UV damage independently of its function in new H3.3 histone deposition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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