Communications Biology (May 2021)

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

  • Mariana G. Ferrarini,
  • Avantika Lal,
  • Rita Rebollo,
  • Andreas J. Gruber,
  • Andrea Guarracino,
  • Itziar Martinez Gonzalez,
  • Taylor Floyd,
  • Daniel Siqueira de Oliveira,
  • Justin Shanklin,
  • Ethan Beausoleil,
  • Taneli Pusa,
  • Brett E. Pickett,
  • Vanessa Aguiar-Pulido

DOI
https://doi.org/10.1038/s42003-021-02095-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Ferrarini & Lal et al. developed a novel bioinformatic pipeline to explore how SARS-CoV-2 interacts with human respiratory cells using public available host gene expression and viral genome sequence data. Several human genes and proteins were predicted to play a role in the viral life cycle and the host response to SARS-CoV-2 infection.