Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle>

Hailiang Sun; Bryan S Kaplan; Minhui Guan; Guihong Zhang; Jianqiang Ye; Li-Ping Long; Sherry Blackmon; Chun-Kai Yang; Meng-Jung Chiang; Hang Xie; Nan Zhao; Jim Cooley; David F Smith; Ming Liao; Carol Cardona; Lei Li; George Peng Wang; Richard Webby; Xiu-Feng Wan

doi:10.1038/emi.2017.3

Emerging Microbes and Infections (Jan 2017)

Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle>

Hailiang Sun,
Bryan S Kaplan,
Minhui Guan,
Guihong Zhang,
Jianqiang Ye,
Li-Ping Long,
Sherry Blackmon,
Chun-Kai Yang,
Meng-Jung Chiang,
Hang Xie,
Nan Zhao,
Jim Cooley,
David F Smith,
Ming Liao,
Carol Cardona,
Lei Li,
George Peng Wang,
Richard Webby,
Xiu-Feng Wan

Affiliations

Hailiang Sun: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Bryan S Kaplan: Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN 38105, USA
Minhui Guan: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Guihong Zhang: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, Guangdong, China
Jianqiang Ye: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Li-Ping Long: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Sherry Blackmon: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Chun-Kai Yang: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Meng-Jung Chiang: Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD 20993, USA
Hang Xie: Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD 20993, USA
Nan Zhao: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA
Jim Cooley: Department of Population Medicine and Pathobiology, College of Veterinary MedicineMississippi State University, Mississippi State, MS 39759, USA
David F Smith: Department of Biochemistry, Glycomics Center, School of MedicineEmory University, Atlanta 30322, GA, USA
Ming Liao: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, Guangdong, China
Carol Cardona: College of Veterinary MedicineUniversity of Minnesota, St Paul, MN 30322, USA
Lei Li: Department of ChemistryGeorgia State University, Atlanta, GA 30302, USA
George Peng Wang: Department of ChemistryGeorgia State University, Atlanta, GA 30302, USA
Richard Webby: Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN 38105, USA
Xiu-Feng Wan: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USA

DOI: https://doi.org/10.1038/emi.2017.3
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.Emerging Microbes & Infections (2017) 6, e17; doi:10.1038/emi.2017.3; published online 12 April 2017

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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