Frontiers in Oncology (Sep 2022)
B cell deficiency promotes the initiation and progression of lung cancer
- Han Wu,
- Han Wu,
- Chen Chen,
- Lixing Gu,
- Lixing Gu,
- Lixing Gu,
- Jiapeng Li,
- Jiapeng Li,
- Jiapeng Li,
- Yunqiang Yue,
- Yunqiang Yue,
- Mengqing Lyu,
- Mengqing Lyu,
- Yeting Cui,
- Yeting Cui,
- Xiaoyu Zhang,
- Xiaoyu Zhang,
- Yu Liu,
- Yu Liu,
- Haichuan Zhu,
- Haichuan Zhu,
- Xinghua Liao,
- Xinghua Liao,
- Tongcun Zhang,
- Tongcun Zhang,
- Fan Sun,
- Fan Sun,
- Weidong Hu
Affiliations
- Han Wu
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Han Wu
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Chen Chen
- Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China
- Lixing Gu
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Lixing Gu
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Lixing Gu
- College of Science, Wuhan University of Science and Technology, Wuhan, China
- Jiapeng Li
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Jiapeng Li
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Jiapeng Li
- College of Science, Wuhan University of Science and Technology, Wuhan, China
- Yunqiang Yue
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Yunqiang Yue
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Mengqing Lyu
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Mengqing Lyu
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Yeting Cui
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Yeting Cui
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Xiaoyu Zhang
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Xiaoyu Zhang
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Yu Liu
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Yu Liu
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Haichuan Zhu
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Haichuan Zhu
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Xinghua Liao
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Xinghua Liao
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Tongcun Zhang
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Tongcun Zhang
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Fan Sun
- College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China
- Fan Sun
- Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, China
- Weidong Hu
- Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
- DOI
- https://doi.org/10.3389/fonc.2022.1006477
- Journal volume & issue
-
Vol. 12
Abstract
Currently commercialized CAR-T cell therapies targeting CD19 and BCMA show great efficacy to cure B cell malignancies. However, intravenous infusion of these CAR-T cells severely destroys both transformed and normal B cells in most tissues and organs, in particular lung, leading to a critical question that what the impact of normal B cell depletion on pulmonary diseases and lung cancer is. Herein, we find that B cell frequency is remarkably reduced in both smoking carcinogen-treated lung tissues and lung tumors, which is associated with advanced cancer progression and worse patient survival. B cell depletion by anti-CD20 antibody significantly accelerates the initiation and progression of lung tumors, which is mediated by repressed tumor infiltration of T cells and macrophage elimination of tumor cells. These findings unveil the overall antitumor activity of B cells in lung cancer, providing novel insights into both mechanisms underlying lung cancer pathogenesis and clinical prevention post CAR-T cell therapy.
Keywords
