Cerebral electrometabolic coupling in disordered and normal states of consciousness
Jitka Annen,
Gianluca Frasso,
Glenn J.M. van der Lande,
Estelle A.C. Bonin,
Marie M. Vitello,
Rajanikant Panda,
Arianna Sala,
Carlo Cavaliere,
Federico Raimondo,
Mohamed Ali Bahri,
Nicholas D. Schiff,
Olivia Gosseries,
Aurore Thibaut,
Steven Laureys
Affiliations
Jitka Annen
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium; Corresponding author
Gianluca Frasso
Energy Efficiency, Samotics Bv, Leiden, the Netherlands
Glenn J.M. van der Lande
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Estelle A.C. Bonin
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Marie M. Vitello
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Rajanikant Panda
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Arianna Sala
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Carlo Cavaliere
IRCCS SYNLAB SDN of Naples, Naples, Italy
Federico Raimondo
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany
Mohamed Ali Bahri
GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium
Nicholas D. Schiff
BMRI, Weill Cornell Medicine, New York, NY, USA
Olivia Gosseries
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Aurore Thibaut
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium
Steven Laureys
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium; Joint International Research Unit on Consciousness, CERVO Brain Research Centre, University Laval, Quebec City, QC, Canada
Summary: We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalography (EEG) within the mesocircuit model framework in patients with disorders of consciousness (DoCs). The mesocircuit hypothesis proposes that subcortical activation facilitates cortical function. We find that the metabolic balance of subcortical mesocircuit areas is informative for diagnosis and is associated with four EEG-based power spectral density patterns, cortical metabolism, and α power in healthy controls and patients with a DoC. Last, regional electrometabolic coupling at the cortical level can be identified in the θ and α ranges, showing positive and negative relations with glucose uptake, respectively. This relation is inverted in patients with a DoC, potentially related to altered orchestration of neural activity, and may underlie suboptimal excitability states in patients with a DoC. By understanding the neurobiological basis of the pathophysiology underlying DoCs, we foresee translational value for diagnosis and treatment of patients with a DoC.
