Ten years of research on the role of BVES/POPDC1 in human disease: a review

Abstract

Ping Han, Yu Lei, Dongxiao Li, Jingmei Liu, Wei Yan, Dean Tian Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Abstract: Since the blood vessel epicardial substance or Popeye domain-containing protein 1 (BVES/POPDC1) was first identified in the developing heart by two independent laboratories in 1999, an increasing number of studies have investigated the structure, function, and related diseases of BVES/POPDC1. During the first 10 years following the discovery of BVES/POPDC1, studies focused mainly on its structure, expression patterns, and functions. Based on these studies, further investigations conducted over the previous decade examined the role of BVES/POPDC1 in human diseases, such as colitis, heart diseases, and human cancers. This review provides an overview of the structure and expression of BVES/POPDC1, mainly focusing on its potential role and mechanism through which it is involved in human cancers. Keywords: blood vessel epicardial substance, Popeye domain-containing protein 1, cancer, Rho  

Keywords

• BVES
• POPDC
• Cancer
• Rho