Multisystem inflammatory syndrome in children associated with 2019 novel coronavirus (SARS-CoV-2) infection

Abstract

Background: MIS-C is a serious condition that appears to be linked to novel coronavirus disease 2019, which is increasingly being reported worldwide. Here we report 10 children diagnosed with MIS-C. Aims and Objective: To describe the clinical and laboratory findings along with treatment and outcome of hospitalized children with multisystem inflammatory syndrome in children (MIS-C) associated with 2019 novel corona virus at SPMCHI, Jaipur. Methods: This was an observational study of 10 children who presented with MIS-C during 10-week duration from 1 October to 20 December 2020. Results: The median age of study was7 years. 8 patients had antibody test positive, 1 antigen by RTPCR was positive and 1 patient was negative. 4(40%) required intensive care unit admission and inotropic support. All patients received steroids, 4 (40%) IVIg, out of 10, 8(80%) survived and 2 (20%) expired. Conclusion: Children with MIS-C present with varied clinical presentation. There was a low RT-PCR positivity with high SARS-CoV-2 antibodies positivity. High index of suspicion is required for this clinical emerging complication of corona in children.

Keywords

• coronavirus
• multisystem inflammatory syndrome in children
• reverse transcription-polymerase chain reaction