Global Pediatric Health (Oct 2022)

Red Blood Cell Alloimmunization in Pediatric group with Beta Thalassemia: A Five-Year Experience

  • Kiran Minhas MBBS FCPS,
  • Muzamil Shabana Ejaz MBBS MCPS DCH FCPS,
  • Alaa Tukruna MD,
  • Maryam Haider MBBS FCPS,
  • Aabiya Arif MBBS,
  • Sameer Saleem Tebha MBBS

DOI
https://doi.org/10.1177/2333794x221132679
Journal volume & issue
Vol. 9

Abstract

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Beta-thalassemia is one of the most frequently occurring hematological disorders in [Removed for blinded peer-review]. Regular blood transfusion is required in almost all cases for management. However, this is associated with significant major complications like red blood cell (RBC) alloimmunization. This retrospective cross-sectional is conducted to evaluate the RBC alloimmunization frequency in children with beta-thalassemia aged between 6 months and 16 years in [Removed for blinded peer-review]. Antibody screening was performed using the Dia clon3 cell antigen panel. If the screening came back positive, a detailed panel was created for the identification of specific antibody. In our sample, the frequency of RBC alloimmunization was found in 22 (26.19%) patients. Of these 22 patients, the Rhesus system was found in most patients 17 (77.3%), followed by Kell 5 (22.7%). RBC alloimmunization was significantly associated with a family history of a blood disorder and splenectomy.