Molecules
(Jun 2022)
Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition
Tingting Zou,
Yuka Sato,
Shuma Kaneyoshi,
Kota Mano,
Rui Yasukawa,
Yoshifumi Nakano,
Satoshi Fujii,
Shinobu Sato,
Shigeori Takenaka
Affiliations
Tingting Zou
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Yuka Sato
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Shuma Kaneyoshi
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Kota Mano
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Rui Yasukawa
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Yoshifumi Nakano
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Satoshi Fujii
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka 820-8502, Japan
Shinobu Sato
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Shigeori Takenaka
Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
DOI
https://doi.org/10.3390/molecules27134053
Journal volume & issue
Vol. 27,
no. 13
Abstract
Read online
Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.
Keywords
WeChat QR code
Close
