Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition

Tingting Zou; Yuka Sato; Shuma Kaneyoshi; Kota Mano; Rui Yasukawa; Yoshifumi Nakano; Satoshi Fujii; Shinobu Sato; Shigeori Takenaka

doi:10.3390/molecules27134053

Molecules (Jun 2022)

Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition

Tingting Zou,
Yuka Sato,
Shuma Kaneyoshi,
Kota Mano,
Rui Yasukawa,
Yoshifumi Nakano,
Satoshi Fujii,
Shinobu Sato,
Shigeori Takenaka

Affiliations

Tingting Zou: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Yuka Sato: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Shuma Kaneyoshi: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Kota Mano: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Rui Yasukawa: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Yoshifumi Nakano: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Satoshi Fujii: Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka 820-8502, Japan
Shinobu Sato: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan
Shigeori Takenaka: Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan

DOI: https://doi.org/10.3390/molecules27134053
Journal volume & issue: Vol. 27, no. 13
p. 4053

Abstract

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Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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