Nature Communications (Nov 2018)
VDAC2 enables BAX to mediate apoptosis and limit tumor development
- Hui San Chin,
- Mark X. Li,
- Iris K. L. Tan,
- Robert L. Ninnis,
- Boris Reljic,
- Kristen Scicluna,
- Laura F. Dagley,
- Jarrod J. Sandow,
- Gemma L. Kelly,
- Andre L. Samson,
- Stephane Chappaz,
- Seong L. Khaw,
- Catherine Chang,
- Andrew Morokoff,
- Kerstin Brinkmann,
- Andrew Webb,
- Colin Hockings,
- Cathrine M. Hall,
- Andrew J. Kueh,
- Michael T. Ryan,
- Ruth M. Kluck,
- Philippe Bouillet,
- Marco J. Herold,
- Daniel H. D. Gray,
- David C. S. Huang,
- Mark F. van Delft,
- Grant Dewson
Affiliations
- Hui San Chin
- Walter and Eliza Hall Institute of Medical Research
- Mark X. Li
- Walter and Eliza Hall Institute of Medical Research
- Iris K. L. Tan
- Walter and Eliza Hall Institute of Medical Research
- Robert L. Ninnis
- Walter and Eliza Hall Institute of Medical Research
- Boris Reljic
- Walter and Eliza Hall Institute of Medical Research
- Kristen Scicluna
- Walter and Eliza Hall Institute of Medical Research
- Laura F. Dagley
- Walter and Eliza Hall Institute of Medical Research
- Jarrod J. Sandow
- Walter and Eliza Hall Institute of Medical Research
- Gemma L. Kelly
- Walter and Eliza Hall Institute of Medical Research
- Andre L. Samson
- Walter and Eliza Hall Institute of Medical Research
- Stephane Chappaz
- Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University
- Seong L. Khaw
- Walter and Eliza Hall Institute of Medical Research
- Catherine Chang
- Walter and Eliza Hall Institute of Medical Research
- Andrew Morokoff
- Department of Surgery, The University of Melbourne
- Kerstin Brinkmann
- Walter and Eliza Hall Institute of Medical Research
- Andrew Webb
- Walter and Eliza Hall Institute of Medical Research
- Colin Hockings
- Walter and Eliza Hall Institute of Medical Research
- Cathrine M. Hall
- Walter and Eliza Hall Institute of Medical Research
- Andrew J. Kueh
- Walter and Eliza Hall Institute of Medical Research
- Michael T. Ryan
- Department of Biochemistry and Molecular Biology, Monash University
- Ruth M. Kluck
- Walter and Eliza Hall Institute of Medical Research
- Philippe Bouillet
- Walter and Eliza Hall Institute of Medical Research
- Marco J. Herold
- Walter and Eliza Hall Institute of Medical Research
- Daniel H. D. Gray
- Walter and Eliza Hall Institute of Medical Research
- David C. S. Huang
- Walter and Eliza Hall Institute of Medical Research
- Mark F. van Delft
- Walter and Eliza Hall Institute of Medical Research
- Grant Dewson
- Walter and Eliza Hall Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-018-07309-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apoptosis that is important for an efficient chemotherapeutic response and to suppress tumor formation.
