Frontiers in Human Neuroscience (Aug 2022)

More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy

  • Chengru Song,
  • Chengru Song,
  • Chengru Song,
  • Chengru Song,
  • Chengru Song,
  • Chengru Song,
  • Chengru Song,
  • Xiaonan Zhang,
  • Xiaonan Zhang,
  • Xiaonan Zhang,
  • Xiaonan Zhang,
  • Xiaonan Zhang,
  • Xiaonan Zhang,
  • Xiaonan Zhang,
  • Shaoqiang Han,
  • Shaoqiang Han,
  • Shaoqiang Han,
  • Shaoqiang Han,
  • Shaoqiang Han,
  • Shaoqiang Han,
  • Shaoqiang Han,
  • Keran Ma,
  • Keran Ma,
  • Keran Ma,
  • Keran Ma,
  • Keran Ma,
  • Keran Ma,
  • Keran Ma,
  • Kefan Wang,
  • Kefan Wang,
  • Kefan Wang,
  • Kefan Wang,
  • Kefan Wang,
  • Kefan Wang,
  • Kefan Wang,
  • Xinyue Mao,
  • Xinyue Mao,
  • Xinyue Mao,
  • Xinyue Mao,
  • Xinyue Mao,
  • Xinyue Mao,
  • Xinyue Mao,
  • Yajun Lian,
  • Xianchang Zhang,
  • Jinxia Zhu,
  • Yong Zhang,
  • Yong Zhang,
  • Yong Zhang,
  • Yong Zhang,
  • Yong Zhang,
  • Yong Zhang,
  • Yong Zhang,
  • Jingliang Cheng,
  • Jingliang Cheng,
  • Jingliang Cheng,
  • Jingliang Cheng,
  • Jingliang Cheng,
  • Jingliang Cheng,
  • Jingliang Cheng

DOI
https://doi.org/10.3389/fnhum.2022.971062
Journal volume & issue
Vol. 16

Abstract

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BackgroundTemporal lobe epilepsy (TLE) is the most prevalent refractory focal epilepsy and is more likely accompanied by cognitive impairment. The fully understanding of the neuronal activity underlying TLE is of great significance.ObjectiveThis study aimed to comprehensively explore the potential brain activity abnormalities affected by TLE and detect whether the changes were associated with cognition.MethodsSix static intrinsic brain activity (IBA) indicators [amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), degree centrality (DC), global signal correlation (GSCorr), and voxel-mirrored homotopic connectivity (VMHC)] and their corresponding dynamic indicators, such as dynamic ALFF (dALFF), dynamic fALFF (dfALFF), dynamic ReHo (dReHo), dynamic DC (dDC), dynamic VMHC (dVMHC), and dynamic GSCorr (dGSCorr), in 57 patients with unilateral TLE and 42 healthy volunteers were compared. Correlation analyses were also performed between these indicators in areas displaying group differences and cognitive function, epilepsy duration, and severity.ResultsMarked overlap was present among the abnormal brain regions detected using various static and dynamic indicators, primarily including increased ALFF/dALFF/fALFF in the bilateral medial temporal lobe and thalamus, decreased ALFF/dALFF/fALFF in the frontal lobe contralateral to the epileptogenic side, decreased fALFF, ReHo, dReHo, DC, dDC, GSCorr, dGSCorr, and VMHC in the temporal neocortex ipsilateral to the epileptogenic foci, decreased dReHo, dDC, dGSCorr, and dVMHC in the occipital lobe, and increased ALFF, fALFF, dfALFF, ReHo, and DC in the supplementary motor area ipsilateral to the epileptogenic foci. Furthermore, most IBA indicators in the abnormal brain region significantly correlated with the duration of epilepsy and several cognitive scale scores (P < 0.05).ConclusionThe combined application of static and dynamic IBA indicators could comprehensively reveal more real abnormal neuronal activity and the impairment and compensatory mechanisms of cognitive function in TLE. Moreover, it might help in the lateralization of epileptogenic foci and exploration of the transmission and inhibition pathways of epileptic activity.

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