Frontiers in Human Neuroscience (Aug 2022)
More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Yajun Lian,
- Xianchang Zhang,
- Jinxia Zhu,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng
Affiliations
- Chengru Song
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Chengru Song
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Chengru Song
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Chengru Song
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Chengru Song
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Chengru Song
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Chengru Song
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Keran Ma
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Keran Ma
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Keran Ma
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Keran Ma
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Keran Ma
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Keran Ma
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Keran Ma
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Kefan Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Kefan Wang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Kefan Wang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Kefan Wang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Kefan Wang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Kefan Wang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Kefan Wang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Xinyue Mao
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xinyue Mao
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xinyue Mao
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xinyue Mao
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xinyue Mao
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xinyue Mao
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Xinyue Mao
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yajun Lian
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xianchang Zhang
- MR Collaboration, Siemens Healthcare Ltd., Beijing, China
- Jinxia Zhu
- MR Collaboration, Siemens Healthcare Ltd., Beijing, China
- Yong Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fnhum.2022.971062
- Journal volume & issue
-
Vol. 16
Abstract
BackgroundTemporal lobe epilepsy (TLE) is the most prevalent refractory focal epilepsy and is more likely accompanied by cognitive impairment. The fully understanding of the neuronal activity underlying TLE is of great significance.ObjectiveThis study aimed to comprehensively explore the potential brain activity abnormalities affected by TLE and detect whether the changes were associated with cognition.MethodsSix static intrinsic brain activity (IBA) indicators [amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), degree centrality (DC), global signal correlation (GSCorr), and voxel-mirrored homotopic connectivity (VMHC)] and their corresponding dynamic indicators, such as dynamic ALFF (dALFF), dynamic fALFF (dfALFF), dynamic ReHo (dReHo), dynamic DC (dDC), dynamic VMHC (dVMHC), and dynamic GSCorr (dGSCorr), in 57 patients with unilateral TLE and 42 healthy volunteers were compared. Correlation analyses were also performed between these indicators in areas displaying group differences and cognitive function, epilepsy duration, and severity.ResultsMarked overlap was present among the abnormal brain regions detected using various static and dynamic indicators, primarily including increased ALFF/dALFF/fALFF in the bilateral medial temporal lobe and thalamus, decreased ALFF/dALFF/fALFF in the frontal lobe contralateral to the epileptogenic side, decreased fALFF, ReHo, dReHo, DC, dDC, GSCorr, dGSCorr, and VMHC in the temporal neocortex ipsilateral to the epileptogenic foci, decreased dReHo, dDC, dGSCorr, and dVMHC in the occipital lobe, and increased ALFF, fALFF, dfALFF, ReHo, and DC in the supplementary motor area ipsilateral to the epileptogenic foci. Furthermore, most IBA indicators in the abnormal brain region significantly correlated with the duration of epilepsy and several cognitive scale scores (P < 0.05).ConclusionThe combined application of static and dynamic IBA indicators could comprehensively reveal more real abnormal neuronal activity and the impairment and compensatory mechanisms of cognitive function in TLE. Moreover, it might help in the lateralization of epileptogenic foci and exploration of the transmission and inhibition pathways of epileptic activity.
Keywords
- cognition
- dynamic
- intrinsic brain activity
- resting-state functional magnetic resonance imaging
- temporal lobe epilepsy